WebMar 26, 2008 · Egr1 DNAzymes suppressed tumor growth without influencing body weight, wound healing, blood coagulation, or other hematologic parameters. Fahmy et al. (2003)found that these agents inhibited endothelial expression of FGF2 (134920), a proangiogenic factor downstream of EGR1, but not of VEGF (192240). WebKeywords: Angiogenesis, Breast Cancer, Prostate Cancer, Systems Biology, EGR1, ACKR1. Abstract: Introduction: Angiogenesis involves the development of new blood vessels. Biochemical signals start this process in the body, which is followed by migration, growth, and differentiation of endothelial cells that line the inside wall of blood vessels.

Entry - *128990 - EARLY GROWTH RESPONSE 1; EGR1 - OMIM

WebJan 7, 2010 · It has been shown that early growth response protein 1 (EGR1) plays a pivotal role in the transcriptional response of endothelial cells to angiogenic growth factors involved in angiogenic... WebNov 17, 2004 · We found that mutant p53 protein can induce the transcription of EGR1 and elevate the expression of EGR1 downstream genes such as vascular endothelial growth factor (VEGF). Furthermore, mutant p53 can associate with EGR1 gene promoter DNA sequences. Knockdown of EGR1 in mutant p53-overproducing cells attenuates colony … aupe hsaa

EGR1 dysregulation defines an inflammatory and leukemic …

WebNov 1, 2007 · The induced EGR1 protein is thought to couple external stimuli to intracellular events by altering the expression of EGR1 target genes such as tissue factor, vascular endothelial growth factor (VEGF), intercellular adhesion molecule 1 (ICAM1), proteins that are common in organ injury. WebOct 2, 2003 · Early growth response factor 1 (Egr-1) is a key transcriptional factor to mediate gene expression after vascular injury. To better understand the role of Egr-1 … WebOct 1, 2003 · Egr-1 is the major isoform expressed in the vasculature and contributes to the pathogenesis of vascular disorders [38]. A study in human umbilical vein endothelial … aupay joshin