Terfenadine and ketoconazole

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WebKetoconazole alters the metabolism of terfenadine in normal men and women and results in the accumulation of unmetabolized parent drug, which is associated with significant prolongation of the corrected QT interval and should be avoided. OBJECTIVE To examine prospectively the effects of ketoconazole on the pharmacokinetics and … Web2 Apr 1993 · The nonsedating antihistamine terfenadine has been linked to torsades de pointes, a cardiac arrhythmia, particularly when prescribed with ketoconazole. Two …

Cardiac Toxicity of Terfenadine - NEJM Journal Watch

WebTéléchargez notre application gratuite. Traduction Context Correcteur Synonymes Conjugaison Documents Dictionnaire Dictionnaire Collaboratif Grammaire Expressio Reverso Corporate Plus Web1 Jul 2010 · Terfenadine and ketoconazole are the most widely used positive reference agents in non-clinical cardiac repolarization safety studies. The aim of the present study … iob bank full name

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WebThe rate of transport of terfenadine and its metabolites hydroxy-terfenadine (HO-T) and azacyclonol across TC7 monolayers was 7.1-, 3.5- and 2.1-fold higher, respectively, in the basolateral to apical direction than it was in the apical to basolateral (AP-BL) direction. ... Ketoconazole increased the AP-BL transport terfenadine dramatically by ... WebOn sait depuis longtemps que, par interaction ou lors d' un surdosage, la terfénadine peut provoquer des troubles du rythme cardiaque, notamment des torsades de pointes pouvant avoir une issue fatale [voir Folia de septembre 1995, d’avril 1997]. Suite à une réévaluation récente, le Comité des Spécialités Pharmaceutiques (CSP) de l ... Web1 Jul 2010 · Terfenadine and ketoconazole are the most widely used positive reference agents in non-clinical cardiac repolarization safety studies. The aim of the present study … ons fast indicators

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Web1 Dec 2013 · As ketoconazole needs acid for its absorption, antacids, H2 antagonists (cimetidine, famotidine, ranitidine) and omeprazole should not be taken for 2 hours after … Web18 Nov 2012 · Br J Dermatol 1992; 126 Suppl. 39: 14–8. Article PubMed Google Scholar. Yun C, Okerholm RA, Guengerich FP. Oxidation of the antihistaminic drug terfenadine in human liver microsomes: role of cytochrome P-450 3A (4) in N-dealkylation and C-hydroxylation. Drug Metab Dispos 1993; 21: 403–9. PubMed CAS Google Scholar. ons fareham addressWeb1 May 1993 · Erythromycin and ketoconazole inhibit metabolism of terfenadine, leading to elevated concentration of the drug, which in turn is associated with prolongation of the QT interval. In a study of the effects of combining ketoconazole with terfenadine, six healthy volunteers were given terfenadine (60 mg every 12 hours) for 7 days, after which oral … ons fax number

"WebTerfenadine (TF) is a highly potent histamine H1 receptor antagonist that in clinically effective doses is free of significant central nervous system side effects. Ketoconazole … " - Terfenadine and ketoconazole

Terfenadine and ketoconazole

Sertraline 100mg/5ml Concentrate for Oral Solution

WebKetoconazole has been shown to be teratogenic (syndactylia and oligodactylia) in the rat when given in the diet at 80 mg/kg/day (10 times the maximum recommended human … Web2 Apr 1993 · The nonsedating antihistamine terfenadine has been linked to torsades de pointes, a cardiac arrhythmia, particularly when prescribed with ketoconazole. Two studies evaluated this potential drug interaction. In the first, investigators gave oral terfenadine (60 mg twice daily) to six healthy volunteers for 7 days.

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WebIn this patient, administration of magnesium sulfate may explain the absence of recurrence. The arrhythmia was most probably due to the combination of itraconazole and terfenadine as torsades de pointes have been described during … Web30 Nov 1993 · Conclusions. —Ketoconazole alters the metabolism of terfenadine in normal men and women and results in the accumulation of unmetabolized parent drug, which is associated with significant prolongation of the corrected QT interval. This drug combination should be avoided. (JAMA. 1993;269:1513-1518)...

Web31 Dec 1998 · Abstract: Terfenadine is a nonsedating H1-antagonist that when overdosed, used with hepatic compromise, or when given with ketoconazole results in accumulation of parent terfenadine, prolongation of the QT interval, and torsades de pointes in susceptible patients. Nine subjects were given the recommended dose of terfenadine (60 mg every 12 … Web11 Dec 1990 · Terfenadine (Seldane) is a commonly prescribed antihistamine that can cause cardiotoxicity in overdoses. This case report describes a 39-year-old woman who …

WebTerfenadine is normally metabolized by CYP3A4 to fexofenadine, which has negligible cardiac effects. Atorvastatin is also a CYP3A4 substrate, and its effects on the … Web1 Dec 1994 · A mathematical model, based on the in vitro Ki values and the usual clinical range of plasma ketoconazole concentrations (1–5 μg/mL; 1.88 − 0.94 μM), predicted that plasma terfenadine levels during coadministration of ketoconazole would increase by a factor ranging from 13‐fold to 59‐fold relative to the same dose of terfenadine given ...

Web24 Dec 2001 · For example, coadministration of ketoconazole with terfenadine has been associated with altered cardiac repolarization leading to QTc interval prolongation and torsades de pointes . Similarly, ventricular dysrhythmias and torsades de pointes have been reported with astemizole, usually with overdosage.

WebThis report describes the first association (exclusive of drug overdose) of symptomatic torsades de pointes occurring with the use of terfenadine in a patient who was taking the … ons feb 2022 rpiWeb• Pemberian bersama-sama dengan terfenadine dan astemizole. • Absorpsi ketoconazole maksimal bila diberikan pada waktu makan. Absorpsinya terganggu kalau sekresi asam lambung berkurang, pada pasien yang diberi obat-obat penetral asam (antasida) harus diberikan 2 jam atau lebih setelah ketoconazole. ons fate解锁Webterfenadine (50 mg/kg), ketoconazole (200 mg/kg) or a combination of terfenadine and ketoconazole. Recording and analysis of waveforms The ECG waveforms were recorded … iob bank iconWebKetoconazole can increase the concentrations terfenadine by inhibition of CYP3A4; since high concentrations of terfenadine can cause cardiac toxicity, increased plasma … ons family spending workbookWebIn treatment 2 (T2) we examined the effect of oral pretreatment with ketoconazole (200 mg daily for 5 days) on the same absorption parameters. Each experiment was divided into … iob bank micr codeWeb14 Apr 2024 · Sertraline does not act as an inhibitor of CYP 3A4, CYP 2C9, CYP 2C19, and CYP 1A2 to a clinically significant degree. This has been confirmed by in-vivo interaction studies with CYP3A4 substrates (endogenous cortisol, carbamazepine, terfenadine, alprazolam), CYP2C19 substrate diazepam, and CYP2C9 substrates tolbutamide, … iob bank ltd share priceWebDOI: 10.1016/S1734-1140(10)70325-X Corpus ID: 4756810; Evaluation of terfenadine and ketoconazole-induced QT prolongation in conscious telemetered guinea pigs. @article{Rajput2010EvaluationOT, title={Evaluation of terfenadine and ketoconazole-induced QT prolongation in conscious telemetered guinea pigs.}, author={Satyendra K. … ons feeding